P.E.A.R.L. Facial: Microneedling with Exosomes & PDRN

Consultations offered at our two convenient locations in Danville and Pleasanton

The P.E.A.R.L. facial is an innovative skin rejuvenation treatment that combines the beneficial properties of microneedling, exosomes, and PDRN. With the P.E.A.R.L. facial, you can soften visible signs of aging, restore skin elasticity, and strengthen the skin barrier, uplifting the health and appearance of your skin.

East Bay Aesthetic Surgery is a premier aesthetic practice in the San Francisco Bay Area led by a board-certified plastic surgeon, Dr. Eric P. Bachelor.

To start working towards more youthful, elastic skin, please schedule a consultation online or call (925) 462-3700.

About the P.E.A.R.L. Facial

The P.E.A.R.L. facial uses a combination of a nutrient-rich topical serum and microneedling. P.E.A.R.L. is an acronym for the cutting-edge ingredients used in the treatment:

  • P – PDRN: PDRN is a salmon DNA derivative that can help elevate your skin’s hydration levels and elasticity, as well as improve tissue regeneration and DNA repair.
  • E – Exosomes: Exosomes can accelerate the pace at which your body heals and regenerates new cells. Exosomes can also stimulate the production of collagen and elastin, two key proteins for maintaining skin elasticity.
  • A – Antioxidants: Antioxidants can protect the skin from extrinsic factors and environmental stressors while simultaneously brightening and evening the tone of your skin.
  • R – Recombinant Growth Factors: Growth factors signal skin cells to function optimally, helping to firm and brighten the skin.
  • L – Amino Acids: Amino acids promote a stronger skin barrier, increased hydration, firmer skin texture, and quicker skin repair. (1)

Microneedling

Microneedling creates controlled micro-punctures that stimulate the production of collagen, leading to improvements in the health, elasticity, and appearance of your skin. It can soften acne scars, visible signs of aging, hyperpigmentation, and other skin imperfections. (2) Microneedling also enhances product absorption, allowing the P.E.A.R.L. formula to activate deep within the skin.

Exosomes

Exosomes are small vesicles that play an integral role in intercellular communication and help transport cellular matter throughout the body. When used for skin rejuvenation, they have been shown to improve the tone, texture, and clarity of skin, as well as reduce scar formation and promote skin repair. (3)

The P.E.A.R.L. facial features hybrid-source exosomes that combine bone marrow-derived and umbilical cord-derived mesenchymal stem cells (MSC) to enhance your overall results. This solution delivers 10 billion pure exosomes of exceptionally high quality to the skin, as well as Biosomes, an advanced synthetic alternative to human-derived exosomes. Each vial delivers over 25 billion pure Biosomes. (1)

PDRN

PDRN (polydeoxyribonucleotides) harnesses the natural regenerative properties of salmon DNA to repair and improve the health of your skin. PDRN can stimulate neocollagenesis and promote tissue regeneration, making it highly beneficial for the skin. Its anti-inflammatory, anti-apoptotic, anti-melanogenetic, tissue-damage-preventing, and anti-ulcerative properties can effectively restore skin vitality. (4)

Candidates

You may be an ideal candidate for the P.E.A.R.L. facial if you are interested in rejuvenating the appearance and health of your skin.

We do not typically recommend this treatment for patients with certain skin conditions, immunosuppression, a history of keloidal scarring, or active infections in the treatment area. (5) Your specialist will finalize your candidacy during your personal consultation.

Personal Consultation

During your personal consultation, one of our specialists will meet with you to create your unique treatment plan. Your specialist will discuss the P.E.A.R.L. facial and what it entails. They will ask you about your medical history, skin concerns, and desired outcomes, and perform a physical evaluation to assess the condition and quality of your skin.

To schedule your consultation, please contact us online or call (925) 462-3700.

Preparing Your Skin for the P.E.A.R.L. Facial

Your specialist may give you a set of detailed instructions on how to prepare your skin for your facial. They may ask that you:

  • Refrain from using harsh or irritating skincare products, such as retinoids, retinols, exfoliants, or chemical peels.
  • Protect your skin with sunscreen when you leave your home.
  • Avoid direct or excessive sun exposure.
  • Discontinue taking medications or supplements that thin your blood.
  • Arrive at your appointment without skincare or makeup products.
  • Remove any facial jewelry ahead of time.

While these instructions are fairly simple, you must follow each one for the best possible results.

Procedure

Your specialist will perform the P.E.A.R.L. facial as an in-office treatment. It usually takes less than 30 minutes to complete, but the exact duration varies depending on your treatment plan.

Your specialist will first cleanse and sanitize your skin to remove any residual skincare products or makeup. They will then use the microneedling device, fashioned with rows of fine needles, on your desired treatment area. As the handpiece moves over your skin, it will create micro-punctures on the surface. After evenly addressing the face, they will then apply the P.E.A.R.L. solution, allowing the formula to absorb into the microchannels and penetrate deep within the skin.

Recovery

After the P.E.A.R.L. facial, you may return to most aspects of your daily routine immediately. However, you may experience redness and tenderness initially. These effects are temporary and will gradually subside on their own. You will need to protect your skin with the appropriate sun protection when leaving the house, and avoid direct or excessive sunlight altogether. You will also need to refrain from using certain skincare products and makeup products until your skin heals.

Results

The P.E.A.R.L. facial offers gradual results, allowing you to see improvements in your skin develop as your collagen levels increase. Your skin will feel softer, smoother, more elastic, and hydrated. Your skin will also look more youthful, clear, and radiant as the treatment reduces visible signs of aging and pigmentation irregularities.

It may take several days to one month for the full, refined results of your treatment to develop, and most patients require several treatment sessions to see their ideal outcomes. However, patients can experience significant improvements after just one treatment session.

Cost of the P.E.A.R.L. Facial in the San Francisco Bay Area

You will receive a personalized cost estimate during your personal consultation. East Bay Aesthetic Plastic Surgery offers financing for those who qualify.

We invite you to schedule a consultation online or call our office at (925) 462-3700.

FAQ

What is the P.E.A.R.L. facial?

The P.E.A.R.L. facial is a skin rejuvenation treatment that consists of microneedling the skin before your specialist applies the P.E.A.R.L. solution. The solution contains both exosomes and PDRN to restore the health and appearance of your skin.

Will my P.E.A.R.L. facial be painful?

The P.E.A.R.L. facial is well-tolerated, with many of our patients describing the feeling of their treatment as a light prickling sensation. If you are more sensitive to pain, your specialist will discuss numbing options with you.

What are exosomes?

Exosomes are nanosized vesicles naturally present in the body that play a vital role in intercellular communication. These vesicles are safe to apply to the skin and can help promote wound healing and regeneration in the areas your specialist applies them.

What is PDRN, and how will it help my skin?

PDRN (polydeoxyribonucleotides) is a solution derived from salmon DNA. This solution can stimulate neocollagenesis and promote tissue regeneration, leading to improvements in the health, elasticity, and overall appearance of your skin.

Is the P.E.A.R.L. facial safe for darker skin tones?

Our specialists can safely perform this procedure for patients with darker skin tones; however, there is a higher risk of post-inflammatory pigmentation for some patients. Your specialist will customize the depth of your treatment to reduce this risk.

Can my specialist combine my P.E.A.R.L. facial with another skin rejuvenation treatment?

Yes, your specialist can combine your facial with another treatment to further enhance the health and appearance of your skin. For more information, please schedule a consultation online.

References

  1. A Fusion of Forces | PEARL by AnteAGE. AnteAGE. Published 2025. Accessed January 19, 2026. https://anteage.com/pages/discover-pearl
  2. Jaiswal S, Sugat Jawade. Microneedling in Dermatology: A Comprehensive Review of Applications, Techniques, and Outcomes. Cureus. 2024;16(9). doi:https://doi.org/10.7759/cureus.70033
  3. Ku YC, Omer Sulaiman H, Anderson SR, Abtahi AR. The Potential Role of Exosomes in Aesthetic Plastic Surgery: A Review of Current Literature. Plastic and Reconstructive Surgery – Global Open. 2023;11(6):e5051. doi:https://doi.org/10.1097/GOX.0000000000005051
  4. Khan A, Wang G, Zhou F, et al. Polydeoxyribonucleotide: A promising skin anti-aging agent. Chinese Journal of Plastic and Reconstructive Surgery. 2022;4(4):187-193. doi:https://doi.org/10.1016/j.cjprs.2022.09.015
  5. Litchman G, Nair PA, Badri T, Kelly SE. Microneedling. Nih.gov. Published September 26, 2022. https://www.ncbi.nlm.nih.gov/books/NBK459344/#article-38285.s4
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